KCNK18 antibody

Catalog No. ABIN5698029

The Rabbit Polyclonal anti-KCNK18 antibody (ABIN5698029) specifically detects KCNK18 in WB and ELISA. The antibody is reactive with Human samples.

Quick Overview for KCNK18 antibody (ABIN5698029)

Target: KCNK18 (Potassium Channel Subfamily K Member 18 (KCNK18))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KCNK18 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-KCNK18 Antibody

Purpose: KCNK18 antibody

Immunogen: potassium channel, subfamily K, member 18

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for KCNK18

Target: KCNK18 (Potassium Channel Subfamily K Member 18 (KCNK18))

Alternative Name: KCNK18

Background:

Synonyms: Potassium channel subfamily K member 18|TWIK-related individual potassium channel|TWIK-related spinal cord potassium channel|KCNK18|TRESK|TRIK

Background: Outward rectifying potassium channel. Produces rapidly activating outward rectifier K(+) currents. May function as background potassium channel that sets the resting membrane potential. Channel activity is directly activated by calcium signal. Activated by the G(q)-protein coupled receptor pathway. The calcium signal robustly activates the channel via calcineurin, whereas the anchoring of 14-3-3/YWHAH interferes with the return of the current to the resting state after activation. Inhibited also by arachidonic acid and other naturally occurring unsaturated free fatty acids. Channel activity is also enhanced by volatile anesthetics, such as isoflurane. Appears to be the primary target of hydroxy-alpha-sanshool, an ingredient of Schezuan pepper. May be involved in the somatosensory function with special respect to pain sensation(By similarity).

Molecular Weight: 44 kDa

Gene ID: 338567

UniProt: Q7Z418