SSRP1 antibody

Catalog No. ABIN5699682

The Rabbit Polyclonal anti-SSRP1 antibody (ABIN5699682) specifically detects SSRP1 in WB, IHC, ELISA and IP. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for SSRP1 antibody (ABIN5699682)

Target: SSRP1 (Structure Specific Recognition Protein 1 (SSRP1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SSRP1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunoprecipitation (IP)

Product Details anti-SSRP1 Antibody

Purpose: SSRP1 antibody

Immunogen: structure specific recognition protein 1

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

HeLa cells were subjected to SDS PAGE followed by western blot with FNab08250(SSRP1 antibody) at dilution of 1:500

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for SSRP1

Target: SSRP1 (Structure Specific Recognition Protein 1 (SSRP1))

Alternative Name: SSRP1

Background:

Synonyms: FACT complex subunit SSRP1|Chromatin-specific transcription elongation factor 80 kDa subunit|Facilitates chromatin transcription complex 80 kDa subunit (FACT 80 kDa subunit, FACTp80)|Facilitates chromatin transcription complex subunit SSRP1|Recombination signal sequence recognition protein 1|Structure-specific recognition protein 1 (hSSRP1)|T160|SSRP1|FACT80

Background: The protein encoded by this gene is a subunit of a heterodimer that, along with SUPT16H, forms chromatin transcriptional elongation factor FACT. FACT interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT and cisplatin-damaged DNA may be crucial to the anticancer mechanism of cisplatin. This encoded protein contains a high mobility group box which most likely constitutes the structure recognition element for cisplatin-modified DNA. This protein also functions as a co-activator of the transcriptional activator p63. An alternatively spliced transcript variant of this gene has been described, but its full-length nature is not known.

Gene ID: 6749

UniProt: Q08945

Pathways: Chromatin Binding