DIS3L2 antibody
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- Target See all DIS3L2 Antibodies
- DIS3L2 (DIS3-Like Exonuclease 2 (DIS3L2))
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Reactivity
- Human, Mouse
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This DIS3L2 antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA
- Immunogen
- DIS3 mitotic control homolog (S. cerevisiae)-like 2
- Isotype
- IgG
- Top Product
- Discover our top product DIS3L2 Primary Antibody
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Buffer
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze / thaw cycles.
- Storage
- -20 °C
- Expiry Date
- 12 months
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- Target
- DIS3L2 (DIS3-Like Exonuclease 2 (DIS3L2))
- Alternative Name
- DIS3L2 (DIS3L2 Products)
- Synonyms
- RGD1560168 antibody, DIS3L2 antibody, DKFZp469O0522 antibody, FAM6A antibody, PRLMNS antibody, hDIS3L2 antibody, 4930429A22Rik antibody, 8030493P09Rik antibody, DIS3-like 3'-5' exoribonuclease 2 antibody, DIS3 like 3'-5' exoribonuclease 2 antibody, DIS3-like exonuclease 2 antibody, Dis3l2 antibody, DIS3L2 antibody, LOC100344728 antibody
- Background
- Synonyms:FAM6A Background:3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem(ES) cells. Essential for correct mitosis, and negatively regulates cell proliferation.
- Molecular Weight
- 65 kDa, 99 kDaa
- Gene ID
- 129563
- UniProt
- Q8IYB7
- Pathways
- Stem Cell Maintenance
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