YTHDC1 antibody
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- Target See all YTHDC1 Antibodies
- YTHDC1 (YTH Domain Containing 1 (YTHDC1))
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Reactivity
- Human, Mouse, Rat
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This YTHDC1 antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA
- Immunogen
- YTH domain containing 1
- Isotype
- IgG
- Top Product
- Discover our top product YTHDC1 Primary Antibody
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- Application Notes
- WB : 1:200-1:1000
- Comment
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MCF-7 cells were subjected to SDS PAGE followed by western blot with FNab09571( YTHDC1 Antibody) at dilution of 1:300
- Restrictions
- For Research Use only
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- Buffer
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze / thaw cycles.
- Storage
- -20 °C
- Expiry Date
- 12 months
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- Target
- YTHDC1 (YTH Domain Containing 1 (YTHDC1))
- Alternative Name
- YTHDC1 (YTHDC1 Products)
- Synonyms
- C80342 antibody, mKIAA1966 antibody, A730098D12Rik antibody, zgc:101592 antibody, MGC89461 antibody, MGC137509 antibody, DKFZp459L1228 antibody, YT521 antibody, YT521-B antibody, Yt521 antibody, YTH domain containing 1 antibody, YTH domain containing 1 L homeolog antibody, Ythdc1 antibody, YTHDC1 antibody, ythdc1 antibody, ythdc1.L antibody
- Background
- Synonyms:KIAA1966, Putative splicing factor YT521, YT521, YT521 B, YTH domain containing 1, YTHDC1 Background:Regulator of alternative splicing that specifically recognizes and binds N6-methyladenosine(m6A)-containing RNAs(PubMed:26318451, PubMed:26876937, PubMed:25242552). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability(PubMed:26318451, PubMed:25242552). Acts as a key regulator of exon-inclusion or exon-skipping during alternative splicing via interaction with mRNA splicing factors SRSF3 and SRSF10(PubMed:26876937). Specifically binds m6A-containing mRNAs and promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites, leading to exon-inclusion during alternative splicing(PubMed:26876937). In contrast, interaction with SRSF3 prevents interaction with SRSF10, a splicing factor that promotes exon skipping: this prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing(PubMed:26876937). May also regulate alternative splice site selection(PubMed:20167602).
- Molecular Weight
- 14kDa
- Gene ID
- 91746
- UniProt
- Q96MU7
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