AJUBA antibody

Catalog No. ABIN5705329

Product Details anti-AJUBA Antibody

Target: AJUBA (Ajuba LIM Protein (AJUBA))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This AJUBA antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Immunogen: jub, ajuba homolog (Xenopus laevis)

Isotype: IgG

Application Details

Application Notes: WB :1:200-1:2000,IHC:1:20-200

Comment:

Transfected HEK-293 cells were subjected to SDS PAGE followed by western blot with FNab00242( JUB Antibody) at dilution of 1:800

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Expiry Date: 12 months

Target Details for AJUBA

Target: AJUBA (Ajuba LIM Protein (AJUBA))

Alternative Name: Ajuba (AJUBA Products)

Synonyms: JUB antibody, Jub antibody, ajuba LIM protein antibody, AJUBA antibody, Ajuba antibody

Background: Synonyms:Ajuba, JUB, Protein ajuba Background:Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, mitosis, cell-cell adhesion, cell differentiation, proliferation and migration. Contributes to the linking and/or strengthening of epithelia cell-cell junctions in part by linking adhesive receptors to the actin cytoskeleton. May be involved in signal transduction from cell adhesion sites to the nucleus. Plays an important role in regulation of the kinase activity of AURKA for mitotic commitment. Also a component of the IL-1 signaling pathway modulating IL-1-induced NFKB1 activation by influencing the assembly and activity of the PRKCZ-SQSTM1-TRAF6 multiprotein signaling complex. Functions as an HDAC-dependent corepressor for a subset of GFI1 target genes. Acts as a transcriptional corepressor for SNAI1 and SNAI2/SLUG-dependent repression of E-cadherin transcription. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Positively regulates microRNA(miRNA)-mediated gene silencing. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1.

Molecular Weight: 57kDa

Gene ID: 84962

UniProt: Q96IF1

Pathways: Chromatin Binding, Cell-Cell Junction Organization