WRAP53 antibody

Catalog No. ABIN5705513

Product Details anti-WRAP53 Antibody

Target: WRAP53 (WD Repeat Containing, Antisense To TP53 (WRAP53))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This WRAP53 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunoprecipitation (IP)

Immunogen: WD repeat containing, antisense to TP53

Isotype: IgG

Application Details

Application Notes: WB:1:500-1:5000,IHC:1:20-1:200,IP:1:200-1:1000

Comment:

human kidney tissue were subjected to SDS PAGE followed by western blot with FNab09523(WRAP53 antibody) at dilution of 1:300

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Expiry Date: 12 months

Target Details for WRAP53

Target: WRAP53 (WD Repeat Containing, Antisense To TP53 (WRAP53))

Alternative Name: WRAP53 (WRAP53 Products)

Synonyms: DKCB3 antibody, TCAB1 antibody, WDR79 antibody, Wdr79 antibody, BC021790 antibody, WD repeat containing antisense to TP53 antibody, WD repeat containing, antisense to TP53 antibody, WD repeat containing, antisense to Trp53 antibody, WRAP53 antibody, Wrap53 antibody

Background: Synonyms:FLJ10385, TCAB1, WDR79, WRAP53 Background:Essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex essential for the replication of chromosome termini that elongates telomeres in most eukaryotes. In the telomerase holoenzyme complex, it controls telomerase localization to Cajal body. Required for delivery of TERC to telomeres during S phase and for telomerase activity. Binds small Cajal body RNAs(scaRNAs). The mRNA encoding this protein plays a critical role in the regulation of p53 expression at the post-transcriptional level, it is involved both in maintaining basal p53 mRNA levels and in p53 induction upon DNA damage.

Molecular Weight: 39kDa

Gene ID: 55135

UniProt: Q9BUR4

Pathways: Telomere Maintenance