TTI1 antibody

Catalog No. ABIN5705553

Product Details anti-TTI1 Antibody

Target: TTI1 (TELO2 Interacting Protein 1 (TTI1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TTI1 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunoprecipitation (IP)

Immunogen: KIAA0406

Isotype: IgG

Application Details

Application Notes: WB:1:500-1:5000,IP:1:500-1:5000

Comment:

HeLa cells were subjected to SDS PAGE followed by western blot with FNab09093( KIAA0406 Antibody) at dilution of 1:1000

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Expiry Date: 12 months

Target Details for TTI1

Target: TTI1 (TELO2 Interacting Protein 1 (TTI1))

Alternative Name: TTI1 (TTI1 Products)

Synonyms: KIAA0406 antibody, smg-10 antibody, 2610036D13Rik antibody, AI449463 antibody, RGD1562582 antibody, TELO2 interacting protein 1 antibody, TTI1 antibody, Tti1 antibody

Background: Synonyms:TELO2-interacting protein 1 homolog,KIAA0406, SMG10,TTI1 Background:Regulator of the DNA damage response(DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase(PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation(IR), ultraviolet(UV) and mitomycin C(MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals.

Molecular Weight: 130kDa

Gene ID: 9675

UniProt: O43156