PIF1 antibody

Catalog No. ABIN5705714

Product Details anti-PIF1 Antibody

Target: PIF1 (PIF1 5'-To-3' DNA Helicase (PIF1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PIF1 antibody is un-conjugated

Application: ELISA, Western Blotting (WB)

Immunogen: PIF1 5'-to-3' DNA helicase homolog (S. cerevisiae)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Expiry Date: 12 months

Target Details for PIF1

Target: PIF1 (PIF1 5'-To-3' DNA Helicase (PIF1))

Alternative Name: PIF1 (PIF1 Products)

Synonyms: C15orf20 antibody, PIF antibody, 4631410M14 antibody, AI449441 antibody, cb934 antibody, fe11d03 antibody, wu:fe11d03 antibody, zgc:56161 antibody, PIF1 5'-to-3' DNA helicase antibody, PIF1 5'-to-3' DNA helicase homolog (S. cerevisiae) antibody, PIF1 antibody, Pif1 antibody, pif1.L antibody, pif1 antibody

Background: Synonyms:C15orf20 Background:DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex(G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks(DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA ends. Releases telomerase by unwinding the short telomerase RNA/telomeric DNA hybrid that is the intermediate in the telomerase reaction. Possesses an intrinsic strand annealing activity.

Gene ID: 80119

UniProt: Q9H611