FOXP3 antibody (N-Term) (FITC)
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- Target See all FOXP3 Antibodies
- FOXP3 (Forkhead Box P3 (FOXP3))
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Binding Specificity
- N-Term
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Reactivity
- Mouse
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Host
- Rat
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Clonality
- Monoclonal
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Conjugate
- This FOXP3 antibody is conjugated to FITC
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Application
- Flow Cytometry (FACS)
- Specificity
- Mouse Foxp3 (Mr ~57 kDa). Does not cross react with Human Foxp3. T regulatory cells (Originally called T suppressor cells) are a subpopulation of T cells. Their major roles are to suppress excess immune response of other cells and to maintain tolerance of self-antigens. Initially, researchers used CD4 and CD25 (IL-2 receptor) to identify T suppress subpopulation and purified CD4+CD25+ T cells were used for T cells Suppression Assay, however some other activated T cells also express CD25.1,2 The most convincible molecular marker of Treg cells is Forkhead box protein 3 (Foxp3) which is expressed in the nucleus.3 Anti-Foxp3 antibodies are now widely applied to identify the roles of Treg cells in the development of many diseases, such as cancer, autoimmune disease, and organ transplantation.4,5,6 Scientists found that the over-activation of Treg cells may cause cancer cells to escape from immune surveillance 5. Conversely, patients with autoimmune diseases such as psoriasis, systemic lupus erythematous (SLE) have relative dysfunction of Foxp3 positive cells.7,8 Immunologists are trying to induce immune tolerance in organ transplantation using Treg cells.6
- Characteristics
- Rat Anti-Mouse Foxp3-FITC
- Immunogen
- N-terminal recombinant Mouse Foxp3
- Clone
- SB168a
- Isotype
- IgG2a
- Top Product
- Discover our top product FOXP3 Primary Antibody
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- Application Notes
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- Applications: Flow cytometry
- Working Dilutions: Flow Cytometry: FITC conjugate < 1.0 g/106 cells AF647 conjugate < 0.2 g/106 cells
- Restrictions
- For Research Use only
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- Concentration
- 0.5 mg/mL
- Buffer
- 0.1 mg in 0.2 mL PBS/Sodium azide
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C
- Storage Comment
- Store at 2- 8°C
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- Target
- FOXP3 (Forkhead Box P3 (FOXP3))
- Alternative Name
- Foxp3 (FOXP3 Products)
- Synonyms
- foxp3 antibody, FOXP3 antibody, AIID antibody, DIETER antibody, IPEX antibody, PIDX antibody, XPID antibody, JM2 antibody, scurfin antibody, sf antibody, RGD1562112 antibody, forkhead box P3 antibody, forkhead box P3a antibody, forkhead box P3 L homeolog antibody, FOXP3 antibody, foxp3a antibody, foxp3 antibody, foxp3.L antibody, Foxp3 antibody
- Pathways
- Chromatin Binding, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Activated T Cell Proliferation
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