Neurexin 1 antibody

Catalog No. ABIN5708329

Product Details anti-Neurexin 1 Antibody

Target: Neurexin 1 (NRXN1)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Neurexin 1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Purification: Antigen affinity purified

Immunogen: A recombinant human protein corresponding to amino acids D141-E294 was used as the immunogen for the Neurexin 1 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the Neurexin 1 antibody should be determined by the researcher.\. Western blot: 0.5-1 μg/mL,FACS: 1-3 μg/10^6 cells,Direct ELISA: 0.1-0.5 μg/mL

Restrictions: For Research Use only

Handling

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: -20 °C

Storage Comment: After reconstitution, the Neurexin 1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Target Details for Neurexin 1

Target: Neurexin 1 (NRXN1)

Alternative Name: Neurexin 1 (NRXN1 Products)

Synonyms: Hs.22998 antibody, PTHSL2 antibody, SCZD17 antibody, CG7050 antibody, CT21808 antibody, Dmel\\CG7050 antibody, Nrx antibody, Nrx1 antibody, dnrx antibody, dnrx-1 antibody, nrx antibody, Nrxn1b antibody, NRXN1 antibody, Nrx-1 antibody, GB13455 antibody, GB18754 antibody, 1700062G21Rik antibody, 9330127H16Rik antibody, A230068P09Rik antibody, mKIAA0578 antibody, neurexin 1 antibody, Neurexin 1 antibody, neurexin I antibody, neurexin 1b antibody, neurexin 1a antibody, NRXN1 antibody, Nrx-1 antibody, Nrxn1 antibody, nrxn1 antibody, nrxn1b antibody, nrxn1a antibody

Background: Neurexin-1-alpha is a protein that in humans is encoded by the NRXN1 gene. This gene encodes a single-pass type I membrane protein that belongs to the neurexin family. Neurexins are cell-surface receptors that bind neuroligins to form Ca(2+)-dependent neurexin/neuroligin complexes at synapses in the central nervous system. This complex is required for efficient neurotransmission and is involved in the formation of synaptic contacts. Three members of this gene family have been studied in detail and are estimated to generate over 3,000 variants through the use of two alternative promoters (alpha and beta) and extensive alternative splicing in each family member. Recently, a third promoter (gamma) was identified for this gene in the 3' region. Mutations in this gene are associated with Pitt-Hopkins-like syndrome-2 and may contribute to susceptibility to schizophrenia.

UniProt: P58400

Pathways: Synaptic Membrane, Skeletal Muscle Fiber Development