KCNJ13 antibody (AA 200-250)

Catalog No. ABIN571906

Product Details anti-KCNJ13 Antibody

Target: KCNJ13 (Potassium Inwardly-Rectifying Channel, Subfamily J, Member 13 (KCNJ13))

Binding Specificity: AA 200-250

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KCNJ13 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Specificity: Specific for KCNJ13.

Cross-Reactivity: Human

Cross-Reactivity (Details): Other species not yet tested but expected to work in rat and mouse.

Purification: IgG

Immunogen: A synthetic peptide from AA 200-250 of human KCNJ13 conjugated to an immunogenic carrier protein was used as the antigen. The peptide shares 95% identity with rat and mouse sequences.

Isotype: IgG

Application Details

Application Notes: IHC, WB. A concentration of 10-50 μg,ml is recommended. The optimal concentration should be determined by the end user. Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Reconstitute in 100 μL of sterile water. Centrifuge to remove any insoluble material.

Handling Advice: Avoid freeze and thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Expiry Date: 12 months

Target Details for KCNJ13

Target: KCNJ13 (Potassium Inwardly-Rectifying Channel, Subfamily J, Member 13 (KCNJ13))

Alternative Name: KCNJ13 (KCNJ13 Products)

Synonyms: kir7.1 antibody, KIR1.4 antibody, KIR7.1 antibody, LCA16 antibody, SVD antibody, Kir7.1 antibody, potassium voltage-gated channel subfamily J member 13 antibody, potassium inwardly-rectifying channel, subfamily J, member 13 antibody, potassium channel, inwardly rectifying subfamily J, member 13 antibody, KCNJ13 antibody, kcnj13 antibody, Kcnj13 antibody

Background: FUNCTION: Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium, as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ13 has a very low single channel conductance, low sensitivity to block by external barium and cesium, and no dependence of its inward rectification properties on the internal blocking particle magnesium. Tissue specificity: Predominantly expressed in small intestine. Expression is also detected in stomach, kidney, and all central nervous system regions tested with the exception of spinal cord. Subcellular location: Membrane, Multi-pass membrane protein. Involvement in disease: Defects in KCNJ13 are the cause of snowflake vitreoretinal degeneration (SVD). SVD is a developmental and progressive hereditary eye disorder that affects multiple tissues within the eye. Diagnostic features of SVD include fibrillar degeneration of the vitreous humor, early-onset cataract, minute crystalline deposits in the neurosensory retina, and retinal detachment.,Inward Rectifier,Inward rectifier potassium channel 13, Potassium channel, inwardly rectifying subfamily J member 13, Inward rectifier K(+) channel Kir7.1

UniProt: O60928