p53 antibody (Ser46)

Catalog No. ABIN5957023

The Rabbit Polyclonal anti-p53 antibody (ABIN5957023) specifically detects p53 in WB and ELISA. The antibody is reactive with Human and Monkey samples.

Quick Overview for p53 antibody (Ser46) (ABIN5957023)

Target: p53 (TP53) (Tumor Protein P53 (TP53))

Reactivity: Human, Monkey

Host: Rabbit

Clonality: Polyclonal

Conjugate: This p53 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-p53 Antibody

Binding Specificity: Ser46

Specificity: Antigen NY-CO-13,BCC7,Cellular tumor antigen p53,FLJ92943,LFS1,Mutant tumor protein 53,p53,p53 tumor suppressor,P53,Phosphoprotein p53,Tp53,Transformation related protein 53,TRP53,Tumor protein 53,Tumor protein p53,Tumor suppressor p53

Purification: Affinity purification

Immunogen: Synthesized peptide derived from human p53 around the non-phosphorylation site of Ser46.

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000, ELISA 1:10000

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 0.5 % BSA and 50 % glycerol,  pH 7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for p53

Target: p53 (TP53) (Tumor Protein P53 (TP53))

Alternative Name: p53

Background: Acts as a tumor suppressor in many tumor types, induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis.

Molecular Weight: 44kDa

Gene ID: 7157

UniProt: P04637

Pathways: p53 Signaling, MAPK Signaling, PI3K-Akt Signaling, Apoptosis, AMPK Signaling, Chromatin Binding, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Hepatitis C, Protein targeting to Nucleus, Autophagy, Warburg Effect