Lamin A/C antibody (Ser22)

Catalog No. ABIN5957130

The Rabbit Polyclonal anti-Lamin A/C antibody has been validated for WB, ELISA and IHC (p). It is suitable to detect Lamin A/C in samples from Human, Mouse and Rat.

Quick Overview for Lamin A/C antibody (Ser22) (ABIN5957130)

Target: Lamin A/C (LMNA)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Lamin A/C antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-Lamin A/C Antibody

Binding Specificity: Ser22

Specificity: 70 kDa lamin,Cardiomyopathy dilated 1A (autosomal dominant),CDCD1,CDDC,CMD1A,CMT2B1,EMD2,FPL,FPLD,FPLD2,HGPS,IDC,Lamin A,Lamin A/C,Lamin A/C like 1,Lamin,Lamin C,Lamin-A/C,LDP1,LFP,LGMD1B,Limb girdle muscular dystrophy 1B (autosomal dominant),LMN 1,LMN A,LMN C,LMN1,LMNA,LMNA,LMNC,LMNL1,Prelamin A/C,PRO1,Renal carcinoma antigen NY REN 32,Renal carcinoma antigen NY-REN-32,Renal carcinoma antigen NYREN32

Purification: Affinity purification

Immunogen: Synthesized peptide derived from human Lamin A/C around the non-phosphorylation site of Ser22.

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000, IHC 1:100-1:300, ELISA 1:10000

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 0.5 % BSA and 50 % glycerol,  pH 7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for Lamin A/C

Target: Lamin A/C (LMNA)

Alternative Name: Lamin A/C

Background: The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants.

Molecular Weight: 74kDa

Gene ID: 4000

UniProt: P02545

Pathways: Apoptosis, Caspase Cascade in Apoptosis, ER-Nucleus Signaling, Protein targeting to Nucleus