Activating signal cointegrator 1,ASC 1,ASC-1,HsT17391,Thyroid hormone receptor interactor 4,Thyroid receptor interacting protein 4,Thyroid receptor-interacting protein 4,TR-interacting protein 4,TRIP 4,TRIP-4,Trip4,TRIP4,ZC2HC5,Zinc finger C2HC5 type
Purification
Affinity purification
Immunogen
Recombinant human Activating signal cointegrator 1 protein
This gene encodes a subunit of the tetrameric nuclear activating signal cointegrator 1 (ASC-1) complex, which associates with transcriptional coactivators, nuclear receptors and basal transcription factors to facilitate nuclear receptors-mediated transcription. This protein is localized in the nucleus and contains an E1A-type zinc finger domain, which mediates interaction with transcriptional coactivators and ligand-bound nuclear receptors, such as thyroid hormone receptor and retinoid X receptor alpha, but not glucocorticoid receptor. Mutations in this gene are associated with spinal muscular atrophy with congenital bone fractures-1 (SMABF1).