JAK3 antibody (Tyr785)

Catalog No. ABIN5959635

The Rabbit Polyclonal anti-JAK3 antibody has been validated for WB, ELISA, IF and IHC (p). It is suitable to detect JAK3 in samples from Human, Mouse and Rat.

Quick Overview for JAK3 antibody (Tyr785) (ABIN5959635)

Target: JAK3 (Janus Kinase 3 (JAK3))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This JAK3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-JAK3 Antibody

Binding Specificity: Tyr785

Specificity: EC 2.7.10.2,JAK 3,JAK L,JAK-3,Jak3,JAK3 HUMAN,JAK3,JAKL,Janus kinase 3 (a protein tyrosine kinase,leukocyte),Janus kinase 3,Janus Kinase3,L JAK,L-JAK,Leukocyte janus kinase,LJAK,Protein tyrosine kinase leukocyte,Tyrosine protein kinase JAK3,Tyrosine-protein kinase JAK3

Purification: Affinity purification

Immunogen: Synthesized peptide derived from human JAK3 around the non-phosphorylation site of Tyr785.

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000, IHC 1:100-1:300, IF 1:200-1:1000, ELISA 1:20000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 0.5 % BSA and 50 % glycerol, pH 7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for JAK3

Target: JAK3 (Janus Kinase 3 (JAK3))

Alternative Name: JAK3

Background: The protein encoded by this gene is a member of the Janus kinase (JAK) family of tyrosine kinases involved in cytokine receptor-mediated intracellular signal transduction. It is predominantly expressed in immune cells and transduces a signal in response to its activation via tyrosine phosphorylation by interleukin receptors. Mutations in this gene are associated with autosomal SCID (severe combined immunodeficiency disease).

Molecular Weight: 125kDa

Gene ID: 3718

UniProt: P52333

Pathways: JAK-STAT Signaling, RTK Signaling, Response to Growth Hormone Stimulus, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, Protein targeting to Nucleus, Activated T Cell Proliferation, Unfolded Protein Response