Phospholipase C gamma 1 antibody (Tyr783)

Catalog No. ABIN5962019

This Rabbit Polyclonal antibody specifically detects Phospholipase C gamma 1 in WB, ELISA and IHC (p). It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for Phospholipase C gamma 1 antibody (Tyr783) (ABIN5962019)

Target: Phospholipase C gamma 1 (PLCG1) (phospholipase C, gamma 1 (PLCG1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Phospholipase C gamma 1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-Phospholipase C gamma 1 Antibody

Binding Specificity: Tyr783

Specificity: 1 phosphatidyl D myo inositol 4 5 bisphosphate,1 phosphatidylinositol 4 5 bisphosphate phosphodiesterase gamma 1,1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1,Inositoltrisphosphohydrolase,Monophosphatidylinositol phosphodiesterase,NCKAP3,Phosphatidylinositol phospholipase C,Phosphoinositidase C,Phosphoinositide phospholipase C,Phosphoinositide phospholipase C-gamma-1,Phospholipase C 148,Phospholipase C gamma 1,Phospholipase C-gamma-1,Phospholipase C-II,PLC gamma 1,PLC II,PLC-148,PLC-gamma-1,PLC-II,PLC1,PLC148,Plcg1,PLCG1,PLCgamma1

Purification: Affinity purification

Immunogen: Synthesized peptide derived from human PLC gamma1 around the non-phosphorylation site of Tyr783.

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000, IHC 1:100-1:300, ELISA 1:10000

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 0.5 % BSA and 50 % glycerol,  pH 7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for Phospholipase C gamma 1

Target: Phospholipase C gamma 1 (PLCG1) (phospholipase C, gamma 1 (PLCG1))

Alternative Name: PLC gamma1

Background: Plays a role in actin reorganization and cell migration. The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. Major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase.

Molecular Weight: 149kDa

Gene ID: 5335

UniProt: P19174

Pathways: RTK Signaling, WNT Signaling, TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Thyroid Hormone Synthesis, Inositol Metabolic Process, Myometrial Relaxation and Contraction, Regulation of Muscle Cell Differentiation, Regulation of G-Protein Coupled Receptor Protein Signaling, Skeletal Muscle Fiber Development, G-protein mediated Events, Signaling Events mediated by VEGFR1 and VEGFR2, Interaction of EGFR with phospholipase C-gamma, VEGFR1 Specific Signals, VEGF Signaling