CBX6 antibody (AA 80-180)

Catalog No. ABIN6138026

Product Details anti-CBX6 Antibody

Target: CBX6 (Chromobox Homolog 6 (CBX6))

Binding Specificity: AA 80-180

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CBX6 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Sequence: LLKARAQAEA LRISDVHFSV KPSASASSPK LHSSAAVHRL KKDIRRCHRM SRRPLPRPDP QGGSPGLRPP ISPFSETVRI INRKVKPREP KRNRIILNLK V

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 80-180 of human CBX6 (NP_055107.3).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for CBX6

Target: CBX6 (Chromobox Homolog 6 (CBX6))

Alternative Name: CBX6 (CBX6 Products)

Synonyms: cbx6 antibody, CBX6 antibody, zgc:101049 antibody, chromobox 6 antibody, chromobox 6 L homeolog antibody, chromobox homolog 6a antibody, cbx6 antibody, CBX6 antibody, Cbx6 antibody, cbx6.L antibody, cbx6a antibody

Background: Component of a Polycomb group (PcG multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Possibly contributes to the target selectivity of the PRC1 complex by binding specific regions of chromatin. Recruitment to chromatin might occur in an H3K27me3-independent fashion (By similarity. May have a PRC1-independent function in embryonic stem cells (By similarity.,CBX6,Epigenetics & Nuclear Signaling,Chromatin Remodeling,CBX6

Molecular Weight: 43 kDa

Gene ID: 23466

UniProt: O95503