CYP11B1 antibody (AA 234-503)

Catalog No. ABIN6139312

Product Details anti-CYP11B1 Antibody

Target: CYP11B1 (Cytochrome P450, Family 11, Subfamily B, Polypeptide 1 (CYP11B1))

Binding Specificity: AA 234-503

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CYP11B1 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: TVQLMFMPRS LSRWTSPKVW KEHFEAWDCI FQYGDNCIQK IYQELAFSRP QQYTSIVAEL LLNAELSPDA IKANSMELTA GSVDTTVFPL LMTLFELARN PNVQQALRQE SLAAAASISE HPQKATTELP LLRAALKETL RLYPVGLFLE RVASSDLVLQ NYHIPAGTLV RVFLYSLGRN PALFPRPERY NPQRWLDIRG SGRNFYHVPF GFGMRQCLGR RLAEAEMLLL LHHVLKHLQV ETLTQEDIKM VYSFILRPSM FPLLTFRAIN

Cross-Reactivity: Human, Mouse

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 234-503 of human CYP11B1 (NP_000488.3).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for CYP11B1

Target: CYP11B1 (Cytochrome P450, Family 11, Subfamily B, Polypeptide 1 (CYP11B1))

Alternative Name: CYP11B1 (CYP11B1 Products)

Background: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane and is involved in the conversion of progesterone to cortisol in the adrenal cortex. Mutations in this gene cause congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency. Transcript variants encoding different isoforms have been noted for this gene.,CYP11B1,CPN1,CYP11B,FHI,P450C11,Cancer,Signal Transduction,Cell Biology & Developmental Biology,Growth factor,Endocrine & Metabolism,Mitochondrial metabolism,Cytochromes,Mitochondrial markers,Lipid Metabolism,Cytochromes,Lipases,Cardiovascular,Lipids,CYP11B1

Molecular Weight: 49 kDa/57 kDa

Gene ID: 1584

UniProt: P15538

Pathways: Metabolism of Steroid Hormones and Vitamin D, Steroid Hormone Biosynthesis, Regulation of Systemic Arterial Blood Pressure by Hormones, C21-Steroid Hormone Metabolic Process, Carbohydrate Homeostasis