DIO3 antibody (AA 70-170)

Catalog No. ABIN6139627

The Rabbit Polyclonal anti-DIO3 antibody (ABIN6139627) specifically detects DIO3 in WB. The antibody is reactive with Human samples.

Quick Overview for DIO3 antibody (AA 70-170) (ABIN6139627)

Target: DIO3 (Deiodinase, Iodothyronine, Type III (DIO3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DIO3 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-DIO3 Antibody

Binding Specificity: AA 70-170

Sequence: HFLGRRRRGQ PEPEVELNSE GEEVPPDDPP ICVSDDNRLC TLASLKAVWH GQKLDFFKQA HEGGPAPNSE VVLPDGFQSQ HILDYAQGNR PLVLNFGSCT U

Cross-Reactivity: Human

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 70-170 of human DIO3 (NP_001353.4).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for DIO3

Target: DIO3 (Deiodinase, Iodothyronine, Type III (DIO3))

Alternative Name: DIO3

Background: The protein encoded by this intronless gene belongs to the iodothyronine deiodinase family. It catalyzes the inactivation of thyroid hormone by inner ring deiodination of the prohormone thyroxine (T4) and the bioactive hormone 3,3',5-triiodothyronine (T3) to inactive metabolites, 3,3',5'-triiodothyronine (RT3) and 3,3'-diiodothyronine (T2), respectively. This enzyme is highly expressed in pregnant uterus, placenta, fetal and neonatal tissues, and thought to prevent premature exposure of developing fetal tissues to adult levels of thyroid hormones. It regulates circulating fetal thyroid hormone concentrations, and thus plays a critical role in mammalian development. Knockout mice lacking this gene exhibit abnormalities related to development and reproduction, and increased activity of this enzyme in infants with hemangiomas causes severe hypothyroidism. This protein is a selenoprotein, containing the rare selenocysteine (Sec) amino acid at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal.,DIO3,5DIII,D3,DIOIII,TXDI3,Cancer,Signal Transduction,Cell Biology & Developmental Biology,Growth factor,Endocrine & Metabolism,Neuroscience,DIO3

Molecular Weight: 33 kDa

Gene ID: 1735

UniProt: P55073

Pathways: Hormone Activity