ERBB4 antibody (AA 1150-1250)

Catalog No. ABIN6140256

This Rabbit Polyclonal antibody specifically detects ERBB4 in WB and IF. It exhibits reactivity toward Humanand has been mentioned in 1 publication.

Quick Overview for ERBB4 antibody (AA 1150-1250) (ABIN6140256)

Target: ERBB4 (V-Erb-A erythroblastic Leukemia Viral Oncogene Homolog 4 (Avian) (ERBB4))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ERBB4 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Product Details anti-ERBB4 Antibody

Binding Specificity: AA 1150-1250

Sequence: YMTPMRDKPK QEYLNPVEEN PFVSRRKNGD LQALDNPEYH NASNGPPKAE DEYVNEPLYL NTFANTLGKA EYLKNNILSM PEKAKKAFDN PDYWNHSLPP R

Cross-Reactivity: Human, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: A synthetic peptide corresponding to a sequence within amino acids 1150-1250 of human ErbB4/HER4 (NP_005226.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IF,1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

References for anti-ERBB4 antibody (ABIN6140256)

Chen, Zhou, Li, Tian, Li, Dong, Zhao, Wei: "Fatty acid synthase affects expression of ErbB receptors in epithelial to mesenchymal transition of breast cancer cells and invasive ductal carcinoma." in: Oncology letters, Vol. 14, Issue 5, pp. 5934-5946, (2017) (PubMed).

Target Details for ERBB4

Target: ERBB4 (V-Erb-A erythroblastic Leukemia Viral Oncogene Homolog 4 (Avian) (ERBB4))

Alternative Name: ERBB4

Background: This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described, however, not all variants have been fully characterized.,ALS19,HER4,p180erbB4,ERBB4,HER4/ErbB4,Cancer,Tumor biomarkers,Signal Transduction,Kinase,Tyrosine kinases,ErbB-HER Signaling Pathway,Cell Biology & Developmental Biology,Growth factor,EGF,Immunology & Inflammation,ERBB4

Molecular Weight: 143 kDa/145 kDa/146 kDa

Gene ID: 2066

UniProt: Q15303

Pathways: RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway