Metabotropic Glutamate Receptor 5 antibody (AA 870-1070)

Catalog No. ABIN6141427

The Rabbit Polyclonal anti-Metabotropic Glutamate Receptor 5 antibody has been validated for WB. It is suitable to detect Metabotropic Glutamate Receptor 5 in samples from Human.

Quick Overview for Metabotropic Glutamate Receptor 5 antibody (AA 870-1070) (ABIN6141427)

Target: Metabotropic Glutamate Receptor 5 (GRM5) (Glutamate Receptor, Metabotropic 5 (GRM5))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Metabotropic Glutamate Receptor 5 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Metabotropic Glutamate Receptor 5 Antibody

Binding Specificity: AA 870-1070

Sequence: GSSGETLRYK DRRLAQHKSE IECFTPKGSM GNGGRATMSS SNGKSVTWAQ NEKSSRGQHL WQRLSIHINK KENPNQTAVI KPFPKSTESR GLGAGAGAGG SAGGVGATGG AGCAGAGPGG PESPDAGPKA LYDVAEAEEH FPAPARPRSP SPISTLSHRA GSASRTDDDV PSLHSEPVAR SSSSQGSLME QISSVVTRFT A

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 870-1070 of human GRM5 (NP_001137303.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Comment:

HIGH QUALITY

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for Metabotropic Glutamate Receptor 5

Target: Metabotropic Glutamate Receptor 5 (GRM5) (Glutamate Receptor, Metabotropic 5 (GRM5))

Alternative Name: GRM5

Background: This gene encodes a member of the G-protein coupled receptor 3 protein family. The encoded protein is a metabatropic glutamate receptor, whose signaling activates a phosphatidylinositol-calcium second messenger system. This protein may be involved in the regulation of neural network activity and synaptic plasticity. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. A pseudogene of this gene has been defined on chromosome 11. Alternative splicing results in multiple transcript variants.,GRM5,GPRC1E,MGLUR5,PPP1R86,mGlu5,Cancer,Signal Transduction,G protein signaling,G-Protein-Coupled Receptors(GPCR),Neuroscience,Neurodegenerative Diseases,GRM5

Molecular Weight: 105 kDa/128 kDa/132 kDa

Gene ID: 2915

UniProt: P41594

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling, Regulation of long-term Neuronal Synaptic Plasticity