MSL2 antibody (AA 328-577)

Catalog No. ABIN6144069

Product Details anti-MSL2 Antibody

Target: MSL2 (Male-Specific Lethal 2 Homolog (MSL2))

Binding Specificity: AA 328-577

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MSL2 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: CTAATPKIAK LNRKRSRSES DSEKVQPLPI STIIRGPTLG ASAPVTVKRE SKISLQPIAT VPNGGTTPKI SKTVLLSTKS MKKSHEHGSK KSHSKTKPGI LKKDKAVKEK IPSHHFMPGS PTKTVYKKPQ EKKGCKCGRA TQNPSVLTCR GQRCPCYSNR KACLDCICRG CQNSYMANGE KKLEAFAVPE KALEQTRLTL GINVTSIAVR NASTSTSVIN VTGSPVTTFL AASTHDDKSL DEAIDMRFDC

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 328-577 of human MSL2 (NP_060603.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for MSL2

Target: MSL2 (Male-Specific Lethal 2 Homolog (MSL2))

Alternative Name: MSL2 (MSL2 Products)

Synonyms: MSL-2 antibody, MSL2L1 antibody, RNF184 antibody, E130103E02Rik antibody, Msl2l1 antibody, Rnf184 antibody, RGD1310355 antibody, MSL complex subunit 2 antibody, male-specific lethal 2 homolog (Drosophila) antibody, MSL2 antibody, Msl2 antibody

Background: Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at lysine 16 which is implicated in the formation of higher-order chromatin structure. Acts as an E3 ubiquitin ligase that promotes monoubiquitination of histone H2B at 'Lys-35' (H2BK34Ub, but not that of H2A. This activity is greatly enhanced by heterodimerization with MSL1. H2B ubiquitination in turn stimulates histone H3 methylation at 'Lys-4' (H3K4me and 'Lys-79' (H3K79me and leads to gene activation, including that of HOXA9 and MEIS1.,MSL2,MSL-2,MSL2L1,RNF184,Epigenetics & Nuclear Signaling,MSL2

Molecular Weight: 54 kDa/62 kDa

Gene ID: 55167

UniProt: Q9HCI7