Pellino 1 antibody (AA 1-250)
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- Target See all Pellino 1 (PELI1) Antibodies
- Pellino 1 (PELI1) (Pellino E3 Ubiquitin Protein Ligase 1 (PELI1))
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Binding Specificity
- AA 1-250
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This Pellino 1 antibody is un-conjugated
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Application
- Western Blotting (WB)
- Sequence
- MFSPDQENHP SKAPVKYGEL IVLGYNGSLP NGDRGRRKSR FALFKRPKAN GVKPSTVHIA CTPQAAKAIS NKDQHSISYT LSRAQTVVVE YTHDSNTDMF QIGRSTESPI DFVVTDTVPG SQSNSDTQSV QSTISRFACR IICERNPPFT ARIYAAGFDS SKNIFLGEKA AKWKTSDGQM DGLTTNGVLV MHPRNGFTED SKPGIWREIS VCGNVFSLRE TRSAQQRGKM VEIETNQLQD GSLIDLCGAT
- Cross-Reactivity
- Rat
- Characteristics
- Polyclonal Antibodies
- Immunogen
- Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human PELI1 (NP_065702.2).
- Isotype
- IgG
- Top Product
- Discover our top product PELI1 Primary Antibody
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- Application Notes
- WB,1:500 - 1:2000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C. Avoid freeze / thaw cycles.
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- Target
- Pellino 1 (PELI1) (Pellino E3 Ubiquitin Protein Ligase 1 (PELI1))
- Alternative Name
- PELI1 (PELI1 Products)
- Synonyms
- 2810468L03Rik antibody, A930031K15Rik antibody, AA409794 antibody, AI586297 antibody, D11Ertd676e antibody, peli1 antibody, peli1.L antibody, pellino1 antibody, xpellino1 antibody, wu:fd12d01 antibody, zgc:153297 antibody, pellino E3 ubiquitin protein ligase 1 antibody, pellino 1 antibody, pellino E3 ubiquitin protein ligase 1 S homeolog antibody, pellino E3 ubiquitin protein ligase 1b antibody, PELI1 antibody, Peli1 antibody, peli1.S antibody, peli1b antibody
- Background
- E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates 'Lys-63'-linked polyubiquitination of IRAK1 allowing subsequent NF-kappa-B activation. Mediates 'Lys-48'-linked polyubiquitination of RIPK3 leading to its subsequent proteasome-dependent degradation, preferentially recognizes and mediates the degradation of the 'Thr-182' phosphorylated form of RIPK3. Negatively regulates necroptosis by reducing RIPK3 expression. Mediates 'Lys-63'-linked ubiquitination of RIPK1.,PELI1,Signal Transduction,Kinase,Immunology & Inflammation,NF-kB Signaling Pathway,PELI1
- Molecular Weight
- 46 kDa
- Gene ID
- 57162
- UniProt
- Q96FA3
- Pathways
- Activation of Innate immune Response, Toll-Like Receptors Cascades
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