PIAS1 antibody (AA 422-651)

Catalog No. ABIN6145592

This Rabbit Polyclonal antibody specifically detects PIAS1 in WB. It exhibits reactivity toward Human.

Quick Overview for PIAS1 antibody (AA 422-651) (ABIN6145592)

Target: PIAS1 (Protein Inhibitor of Activated STAT, 1 (PIAS1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PIAS1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-PIAS1 Antibody

Binding Specificity: AA 422-651

Sequence: VQEVSASYNG VDGCLSSTLE HQVASHHQSS NKNKKVEVID LTIDSSSDEE EEEPSAKRTC PSLSPTSPLN NKGILSLPHQ ASPVSRTPSL PAVDTSYINT SLIQDYRHPF HMTPMPYDLQ GLDFFPFLSG DNQHYNTSLL AAAAAAVSDD QDLLHSSRFF PYTSSQMFLD QLSAGGSTSL PTTNGSSSGS NSSLVSSNSL RESHSHTVTN RSSTDTASIF GIIPDIISLD

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 422-651 of human PIAS1 (NP_057250.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for PIAS1

Target: PIAS1 (Protein Inhibitor of Activated STAT, 1 (PIAS1))

Alternative Name: PIAS1

Background: This gene encodes a member of the protein inhibitor of activated STAT (PIAS) family. PIAS proteins function as SUMO E3 ligases and play important roles in many cellular processes by mediating the sumoylation of target proteins. This protein plays a central role as a transcriptional coregulator of numerous cellular pathways includign the STAT1 and nuclear factor kappaB pathways. Alternate splicing results in multiple transcript variants.,PIAS1,DDXBP1,GBP,GU/RH-II,ZMIZ3,Epigenetics & Nuclear Signaling,Nuclear Receptor Signaling,Cell Biology & Developmental Biology,Ubiquitin,Ubiquitin-Proteasome Signaling Pathway,Immunology & Inflammation,IL-6 Receptor Signaling Pathway,PIAS1

Molecular Weight: 36 kDa/71 kDa/72 kDa

Gene ID: 8554

UniProt: O75925

Pathways: JAK-STAT Signaling, Interferon-gamma Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Muscle Cell Differentiation, Hepatitis C