FAK antibody (AA 700-800)

Catalog No. ABIN6146423

This anti-FAK antibody is a Rabbit Polyclonal antibody detecting FAK in WB, IHC, IF and IP. Suitable for Human. This Primary Antibody has been cited in 1 publication.

Quick Overview for FAK antibody (AA 700-800) (ABIN6146423)

Key Features:

• High quality FAK Primary Antibody for the detection of PTK2.
• Reliable product with high standard validation data

Target: FAK (PTK2) (PTK2 Protein tyrosine Kinase 2 (PTK2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FAK antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)

Product Details anti-FAK Antibody

Binding Specificity: AA 700-800

Sequence: TVSWDSGGSD EAPPKPSRPG YPSPRSSEGF YPSPQHMVQT NHYQVSGYPG SHGITAMAGS IYPGQASLLD QTDSWNHRPQ EIAMWQPNVE DSTVLDLRGI G

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Immunogen: A synthetic peptide corresponding to a sequence within amino acids 700-800 of human FAK (NP_722560.1).

Isotype: IgG

Product Specific Information:

What can the FAK Antibody ABIN6146423 be used for?: This polyclonal FAK Antibody detects FAK. The FAK Antibody has been validated for various applications and can be used for the detection of FAK and derivatives by Western Blotting, Immunohistochemistry, Immunofluorescence, Immunoprecipitation.

What validation data is available for this FAK Antibody?: The primary antibody is referenced in 1 publications and is characterized by a proven, very high reliability. It has currently 7 product images that show its performance in a variety of applications. The product is currently available in 20 μL, 100 μL, 500 μL, 1000 μL quantities. FAK Antibody for the detection of FAK and derivatives.

What is the function of FAK?: This gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Activation of this gene may be an important early step in cell growth and intracellular signal transduction pathways triggered in response to certain neural peptides or to cell interactions with the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene, but the full-length natures of only three of them have been determined. [provided by RefSeq, Dec 2010].

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200,IP,1:50 - 1:100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

References for anti-FAK antibody (ABIN6146423)

Shen, Sun, Sun, Li, Wu, Li, Chen, Liu, Cui, Zhou: "ARRDC3 suppresses colorectal cancer progression through destabilizing the oncoprotein YAP." in: FEBS letters, Vol. 592, Issue 4, pp. 599-609, (2019) (PubMed).

Target Details for FAK

Target: FAK (PTK2) (PTK2 Protein tyrosine Kinase 2 (PTK2))

Alternative Name: PTK2

Background: This gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Activation of this gene may be an important early step in cell growth and intracellular signal transduction pathways triggered in response to certain neural peptides or to cell interactions with the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene.,FADK,FAK,FAK1,FRNK,PPP1R71,p125FAK,pp125FAK,PTK2,Cancer,Signal Transduction,G protein signaling,G2/M DNA Damage Checkpoint,Kinase,Tyrosine kinases,PI3K-Akt Signaling Pathway,ErbB-HER Signaling Pathway,MAPK-Erk Signaling Pathway,Cell Biology & Developmental Biology,Apoptosis,Cytoskeleton,Actins,Extracellular Matrix,Immunology & Inflammation,Cardiovascular,Angiogenesis,PTK2

Molecular Weight: 39 kDa/48 kDa/63 kDa/99 kDa/114 kDa/119 kDa/120 kDa

Gene ID: 5747

UniProt: Q05397

Pathways: Response to Growth Hormone Stimulus, CXCR4-mediated Signaling Events, Smooth Muscle Cell Migration, Signaling of Hepatocyte Growth Factor Receptor, VEGF Signaling