SLC8A1 antibody (AA 250-520)

Catalog No. ABIN6148050

Product Details anti-SLC8A1 Antibody

Target: SLC8A1 (Solute Carrier Family 8 (Sodium/calcium Exchanger), Member 1 (SLC8A1))

Binding Specificity: AA 250-520

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SLC8A1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Sequence: WVADRRLLFY KYVYKRYRAG KQRGMIIEHE GDRPSSKTEI EMDGKVVNSH VENFLDGALV LEVDERDQDD EEARREMARI LKELKQKHPD KEIEQLIELA NYQVLSQQQK SRAFYRIQAT RLMTGAGNIL KRHAADQARK AVSMHEVNTE VTENDPVSKI FFEQGTYQCL ENCGTVALTI IRRGGDLTNT VFVDFRTEDG TANAGSDYEF TEGTVVFKPG DTQKEIRVGI IDDDIFEEDE NFLVHLSNVK VSSEASEDGI LEANHVSTLA C

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 250-520 of human SLC8A1 (NP_066920.1).

Isotype: IgG

Application Details

Application Notes: WB,1:1000 - 1:2000,IHC,1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for SLC8A1

Target: SLC8A1 (Solute Carrier Family 8 (Sodium/calcium Exchanger), Member 1 (SLC8A1))

Alternative Name: SLC8A1 (SLC8A1 Products)

Synonyms: NCX1 antibody, AI852629 antibody, AV344025 antibody, D930008O12Rik antibody, Ncx1 antibody, Ncx antibody, SLC8A1 antibody, ncx1n antibody, solute carrier family 8 member A1 antibody, solute carrier family 8 (sodium/calcium exchanger), member 1 antibody, solute carrier family 8 (sodium/calcium exchanger), member 1b antibody, sodium/calcium exchanger 1 antibody, SLC8A1 antibody, Slc8a1 antibody, slc8a1b antibody, Tsp_07038 antibody

Background: In cardiac myocytes, Ca(2+) concentrations alternate between high levels during contraction and low levels during relaxation. The increase in Ca(2+) concentration during contraction is primarily due to release of Ca(2+) from intracellular stores. However, some Ca(2+) also enters the cell through the sarcolemma (plasma membrane). During relaxation, Ca(2+) is sequestered within the intracellular stores. To prevent overloading of intracellular stores, the Ca(2+) that entered across the sarcolemma must be extruded from the cell. The Na(+)-Ca(2+) exchanger is the primary mechanism by which the Ca(2+) is extruded from the cell during relaxation. In the heart, the exchanger may play a key role in digitalis action. The exchanger is the dominant mechanism in returning the cardiac myocyte to its resting state following excitation.,SLC8A1,NCX1,Cancer,Signal Transduction,Endocrine & Metabolism,Neuroscience,Calcium Signaling,Cardiovascular,Hypoxia,Heart,Contractility,SLC8A1

Molecular Weight: 104 kDa/107 kDa/108 kDa

Gene ID: 6546

UniProt: P32418

Pathways: Myometrial Relaxation and Contraction