beta Amyloid antibody (C-Term) (Biotin)

Catalog No. ABIN614816

The Mouse Monoclonal anti-beta Amyloid antibody is suitable to detect beta Amyloid in samples from Human. It has been validated for EIA and ELISA (Detection).

Quick Overview for beta Amyloid antibody (C-Term) (Biotin) (ABIN614816)

Target: beta Amyloid (Abeta) (Amyloid beta (Abeta))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This beta Amyloid antibody is conjugated to Biotin

Application: Enzyme Immunoassay (EIA), ELISA (Detection)

Clone: CV9 7B10

Product Details anti-beta Amyloid Antibody (Biotin)

Binding Specificity: C-Term

Sequence: GLMVGGVV

Specificity: This antibody recognizes the C-terminal sequence (MVGGVVIA) of Aβ40 and full length Aβ40. The antibody does not cross react with amyloid beta peptide 42 in dot blotting and ELISA. Cross-reactivity to amyloid beta peptide 43 is less than 1 % in ELISA.

Cross-Reactivity (Details): Species reactivity (tested):Human.

Purification: Protein G affinity chromatohraphy

Immunogen: C-terminal amino acid sequence of human beta amyloid peptide 40, conjugated with KLH

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 0.01 M PBS, pH 7.0 ± 0.1, 0.1 % Proclin-300, 1 % gelatin

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store (in aliquots) at -20 °C.

Target Details for beta Amyloid

Target: beta Amyloid (Abeta) (Amyloid beta (Abeta))

Alternative Name: Amyloid beta

Background: Amyloid beta precursor protein gene (ABPP) encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Multiple transcript variants encoding several different isoforms have been found for this gene. Isoform APP695 is the predominant form in neuronal tissue, isoform APP751 and isoform APP770 are widely expressed in nonneuronal cells. Isoform APP751 is the most abundant form in T lymphocytes. ABPP is expressed in all fetal tissues examined with the highest levels in brain, kidney, heart and spleen with weak expression observed in liver, ABPP is induced during neuronal differentiation. In the adult brain, highest expression of ABPP gene is found in the frontal lobe of the cortex and in the anterior perisylvian cortex opercular gyri, moderate expression in the cerebellar cortex, the posterior perisylvian cortex opercular gyri and the temporal associated cortex. Weak expression is found in the striate, extra striate and motor cortices. Mutations in ABPP have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy).

Gene ID: 351

Pathways: Inflammasome