beta Amyloid antibody (C-Term) (Biotin)

Catalog No. ABIN614820

The Biotin-conjugated Mouse Monoclonal anti-beta Amyloid antibody (ABIN614820) specifically detects beta Amyloid in EIA and ELISA (Detection). The antibody is reactive with Human samples.

Quick Overview for beta Amyloid antibody (C-Term) (Biotin) (ABIN614820)

Target: beta Amyloid (Abeta) (Amyloid beta (Abeta))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This beta Amyloid antibody is conjugated to Biotin

Application: Enzyme Immunoassay (EIA), ELISA (Detection)

Product Details anti-beta Amyloid Antibody (Biotin)

Binding Specificity: C-Term

Sequence: MVGGVVIA

Specificity: This antibody recognizes the C-terminal sequence (MVGGVVIA) of Aβ42 and full length Aβ42. The antibody does not cross react with amyloid beta peptide 40 in dot blotting and ELISA. Cross-reactivity to amyloid beta peptide 43 is less than 1 % in ELISA.

Cross-Reactivity (Details): Species reactivity (tested):Human and other primates, Mouse, Rat.

Purification: Protein G affinity chromatography

Immunogen: C-terminal of human beta amyloid peptide 42, conjugated with KLH

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 0.01 M PBS, pH 7.0 ± 0.1, 0.1 % Proclin-300, 1 % Gelatin

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store (in aliquots) at -20 °C.

Target Details for beta Amyloid

Target: beta Amyloid (Abeta) (Amyloid beta (Abeta))

Alternative Name: Amyloid beta

Background: Amyloid beta peptide 42 (Aβ42) is best known for its role in the formation of senile plaques in the brain of patients with Alzheimer's disease. Aβ42 and Aβ40 are the two major amyloid peptides that are produced after cleavage of amyloid precursor protein by secretases. Aβ42 (42 amino acids) is very fibrillogenic. The beta pleated structure of Aβ42 constituents the initial and key component of the insoluble amyloid fibril in senile plaque. It is widely accepted that Aβ42 contributes to the pathogenesis of Alzheimer's disease. One proposition is that the deposition of amyloid fibril onto the brain tissue results in Alzheimer's disease. Another is that the neurotoxicity of Aβ42 oligomer is the cause of the disease.

Gene ID: 351

Pathways: Inflammasome