COL17A1 antibody (Chain alpha 1)

Catalog No. ABIN615636

The Rabbit Polyclonal anti-COL17A1 antibody (ABIN615636) specifically detects COL17A1 in IHC (fro). The antibody is reactive with Mouse samples.

Quick Overview for COL17A1 antibody (Chain alpha 1) (ABIN615636)

Target: COL17A1 (Collagen, Type XVII, alpha 1 (COL17A1))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This COL17A1 antibody is un-conjugated

Application: Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-COL17A1 Antibody

Binding Specificity: Chain alpha 1

Specificity: Recognizes Mouse Collagen type XVII

Purification: Ig Fraction

Immunogen: Mouse COL17A Genename: Col17a1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Reconstitution: Restore in aqua bidest to initial volume

Buffer: PBS pH 7.4

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store lyophilized at 2-8 °C and reconstituted at -20 °C.

Target Details for COL17A1

Target: COL17A1 (Collagen, Type XVII, alpha 1 (COL17A1))

Background: Unlike most collagens, collagen XVII is a transmembrane protein. Collagen XVII is a structural component of hemidesmosomes, multiprotein complexes at the dermal epidermal basement membrane zone that mediate adhesion of keratinocytes to the underlying membrane. Mutations in the gene coding for collagen XVII are associated with both generalized atrophic benign and junctional epidermolysis bullosa. Two homotrimeric forms of type XVII collagen exist. The full length form is the transmembrane protein. A soluble form, referred to as either ectodomain or LAD 1, is generated by proteolytic processing of the full length form. Two transcript variants, one resulting from alternative splicing in the 3' UTR, have been identified for this gene.Synonyms: 180 kDa bullous pemphigoid antigen 2, BP180, BPAG2, Bullous pemphigoid antigen 2, COL17A1, LABD97, LAD-1

Gene ID: 12821

NCBI Accession: NP_031758

UniProt: Q07563