COL17A1 antibody (Chain alpha 1)

Catalog No. ABIN615636

Product Details anti-COL17A1 Antibody

Target: COL17A1 (Collagen, Type XVII, alpha 1 (COL17A1))

Binding Specificity: Chain alpha 1

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This COL17A1 antibody is un-conjugated

Application: Immunohistochemistry (Frozen Sections) (IHC (fro))

Specificity: Recognizes Mouse Collagen type XVII

Purification: Ig Fraction

Immunogen: Mouse COL17A Genename: Col17a1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Reconstitution: Restore in aqua bidest to initial volume

Buffer: PBS pH 7.4

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store lyophilized at 2-8 °C and reconstituted at -20 °C.

Target Details for COL17A1

Target: COL17A1 (Collagen, Type XVII, alpha 1 (COL17A1))

Abstract: COL17A1 Products

Synonyms: col17a1 antibody, fk89a06 antibody, si:ch211-223p8.6 antibody, wu:fk89a06 antibody, COL17A1 antibody, BA16H23.2 antibody, BP180 antibody, BPA-2 antibody, BPAG2 antibody, LAD-1 antibody, Bpag antibody, Bpag2 antibody, collagen type XVII alpha 1 chain antibody, collagen, type XVII, alpha 1b antibody, collagen, type XVII, alpha 1 antibody, Col17a1 antibody, col17a1b antibody, COL17A1 antibody

Background: Unlike most collagens, collagen XVII is a transmembrane protein. Collagen XVII is a structural component of hemidesmosomes, multiprotein complexes at the dermal epidermal basement membrane zone that mediate adhesion of keratinocytes to the underlying membrane. Mutations in the gene coding for collagen XVII are associated with both generalized atrophic benign and junctional epidermolysis bullosa. Two homotrimeric forms of type XVII collagen exist. The full length form is the transmembrane protein. A soluble form, referred to as either ectodomain or LAD 1, is generated by proteolytic processing of the full length form. Two transcript variants, one resulting from alternative splicing in the 3' UTR, have been identified for this gene.Synonyms: 180 kDa bullous pemphigoid antigen 2, BP180, BPAG2, Bullous pemphigoid antigen 2, COL17A1, LABD97, LAD-1

Gene ID: 12821

NCBI Accession: NP_031758

UniProt: Q07563