CD46 antibody (APC)

Catalog No. ABIN616769

The Mouse Monoclonal anti-CD46 antibody has been validated for FACS. It is suitable to detect CD46 in samples from Human and Cow.

Quick Overview for CD46 antibody (APC) (ABIN616769)

Target: CD46

Reactivity: Human, Cow

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD46 antibody is conjugated to APC

Application: Flow Cytometry (FACS)

Clone: MEM-258

Product Details anti-CD46 Antibody (APC)

Specificity: This antibody recognizes an epitope on SCR4 (the membrane-proximal SCR) domain of CD46 (Membrane cofactor protein). CD46 is 56-66 kDa dimeric transmembrane protein expressed on T and B lymphocytes, platelets, monocytes, granulocytes, endothelial cells, epithelial cells and fibroblast, it is negative on erythrocytes.

Cross-Reactivity (Details): Species reactivity (tested):Human, bovine

Immunogen: HPB-ALL human T cell line

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: Phosphate buffered saline (PBS) containing 15 mM sodium azide and 0.2 % (w/v) high-grade protease free Bovine Serum Albumin (BSA) as a stabilizing agent

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Dilute only prior to immediate use

Storage: 4 °C

Storage Comment: Store the antibody (undiluted) at 2-8 °C. DO NOT FREEZE! Freezing alkaline phosphatase conjugates will result in a substantial loss of enzymatic activity.

Target Details for CD46

Target: CD46

Alternative Name: CD46 / MCP

Background: CD46 (MCP, membrane cofactor protein) is a multifunctional cell surface transmembrane protein that binds and inactivates C3b and C4b complement fragments, regulates T cell-induced inflammatory responses by either inhibiting (CD46-1 isoform) or increasing (CD46-2 isoform) the contact hypersensitivity reaction. CD46 also serves as a receptor for several human pathogens (both bacteria and viruses), and its ligation alteres T lymphocyte polarization toward antigen-presenting cells or target cells, inhibiting lymphocyte function. CD46 is a protector of placental tissue and is also expressed on the inner acrosomal membrane of spermatozoa.Synonyms: MIC10, Membrane cofactor protein, TLX, Trophoblast leukocyte common antigen

Gene ID: 4179

NCBI Accession: NP_002380

UniProt: P15529

Pathways: Regulation of Actin Filament Polymerization