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CD46 antibody (CF®405S)

This anti-CD46 antibody is a Mouse Monoclonal antibody detecting CD46 in FACS and IF. Suitable for Human.
Catalog No. ABIN6187826

Quick Overview for CD46 antibody (CF®405S) (ABIN6187826)

Target

See all CD46 Antibodies
CD46

Reactivity

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Human

Host

  • 91
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Mouse

Clonality

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Monoclonal

Conjugate

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  • 1
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  • 1
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This CD46 antibody is conjugated to CF®405S

Application

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Flow Cytometry (FACS), Immunofluorescence (IF)

Clone

122-2
  • Purpose

    Mouse Monoclonal anti-CD46 (122.2), CF405S Conjugate

    Characteristics

    CD46 acts as a cofactor for complement factor I, a serine protease, which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. It may be involved in the fusion of the spermatozoa with the oocyte during fertilization. CD46 acts as a co-stimulatory factor for T-cells, which induces the differentiation of CD4 into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype in T-cells by binding to CD46. Primary antibodies are available purified, or with a selection of fluorescent CF® dyes and other labels. CF® dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

    Immunogen

    Recombinant human CD46 protein

    Isotype

    IgG1 kappa
  • Application Notes

    Immunofluorescence 0.5-1 μg/mL
    • Flow Cytometry 0.5-1 μg/million cells/0.1 mL
    • Optimal dilution for a specific application should be determined by user

    Comment

    HeLa, K-562 or MOLT-4 cells. Kidney

    Restrictions

    For Research Use only
  • Format

    Liquid

    Concentration

    100 μg/mL

    Buffer

    PBS/0.1 % BSA/0.05 % azide

    Preservative

    Sodium azide

    Precaution of Use

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Handling Advice

    Protect from light
  • Target

    CD46

    Alternative Name

    CD46

    Background

    AHUS2, CD46 antigen complement regulatory protein, Complement membrane cofactor protein, MCP, Measles virus receptor, Membrane cofactor protein, MIC10, TLX, Trophoblast leucocyte common antigen

    Molecular Weight

    56-66 kDa

    Gene ID

    4179, 510402

    UniProt

    P15529

    Pathways

    Regulation of Actin Filament Polymerization
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