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Neutrophil Cytosolic Factor 4, 40kDa (NCF4) antibody Primary Antibody

NCF4 Reactivity: Human, Mouse, Rat IHC, WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6219288
$350.30
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  • Target
    Neutrophil Cytosolic Factor 4, 40kDa (NCF4)
    Reactivity
    Human, Mouse, Rat
    • 66
    • 42
    • 26
    • 5
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    Host
    Rabbit
    • 56
    • 7
    • 6
    Clonality
    Polyclonal
    Conjugate
    Un-conjugated
    • 40
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Application
    Immunohistochemistry (IHC), Western Blotting (WB)
    • 44
    • 20
    • 19
    • 13
    • 8
    • 4
    • 3
    • 2
    • 2
    Purification
    Affinity purification
    Immunogen
    Recombinant protein of human NCF4
    Isotype
    IgG
  • Application Notes
    Recommended dilutions: WB: 1:500-1:2000, IHC: 1:50-1:200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid freeze / thaw cycles
    Storage
    -20 °C/-80 °C
  • Target
    Neutrophil Cytosolic Factor 4, 40kDa (NCF4)
    Alternative Name
    NCF4 (NCF4 Antibody Abstract)
    Synonyms
    p40phox, AI451400, NCF, P40PHOX, SH3PXD4, neutrophil cytosolic factor 4, ncf4, Ncf4, NCF4
    Background
    The protein encoded by this gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI kinase, which suggests its role in PI kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
    Synonyms: MGC3810, NCF, P40PHOX, SH3PXD4
    Gene ID
    4689
    UniProt
    Q15080
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