ACER2 antibody

Catalog No. ABIN6241552

Product Details anti-ACER2 Antibody

Target: ACER2 (Alkaline Ceramidase 2 (ACER2))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ACER2 antibody is un-conjugated

Application: Western Blotting (WB)

Immunogen: Synthetic Peptide

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Storage: 4 °C,-20 °C

Target Details for ACER2

Target: ACER2 (Alkaline Ceramidase 2 (ACER2))

Alternative Name: ASAH3L (ACER2 Products)

Synonyms: ASAH3L antibody, asah3l antibody, ALKCDase2 antibody, 2410116I05Rik antibody, Asah3l antibody, CRG-L1 antibody, maCER2 antibody, alkaline ceramidase 2 antibody, alkaline ceramidase 2 S homeolog antibody, ACER2 antibody, acer2.S antibody, acer2 antibody, Acer2 antibody

Background: Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. Unsaturated long-chain ceramides are the best substrates, saturated long-chain ceramides and unsaturated very long-chain ceramides are good substrates, whereas saturated very long-chain ceramides and short-chain ceramides were poor substrates. The substrate preference is D-erythro-C(18:1)-, C(20:1)-, C(20:4)-ceramide > D-erythro-C(16:0)-, C(18:0), C(20:0)- ceramide > D-erythro-C(24:1)-ceramide > D-erythro-C(12:0)- ceramide, D-erythro-C(14:0)-ceramides > D-erythro-C(24:0)-ceramide > D-erythro-C(6:0)-ceramide. Inhibits the maturation of protein glycosylation in the Golgi complex, including that of integrin beta-1 (ITGB1) and of LAMP1, by increasing the levels of sphingosine. Inhibits cell adhesion by reducing the level of ITGB1 in the cell surface. May have a role in cell proliferation and apoptosis that seems to depend on the balance between sphingosine and sphingosine-1-phosphate.

UniProt: Q5QJU3

Pathways: Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process