PDCD6 antibody (AA 103-137)

Catalog No. ABIN6242573

This Rabbit Polyclonal antibody specifically detects PDCD6 in WB. It exhibits reactivity toward Mouse.

Quick Overview for PDCD6 antibody (AA 103-137) (ABIN6242573)

Target: PDCD6 (Programmed Cell Death 6 (PDCD6))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PDCD6 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: RB49787

Product Details anti-PDCD6 Antibody

Binding Specificity: AA 103-137

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This PDCD6 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 103-137 amino acids from the Central region of human PDCD6.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

Target Details for PDCD6

Target: PDCD6 (Programmed Cell Death 6 (PDCD6))

Alternative Name: PDCD6

Background: Calcium-binding protein required for T-cell receptor-, Fas-, and glucocorticoid-induced cell death. May mediate Ca(2+)- regulated signals along the death pathway (By similarity). Calcium-dependent adapter necessary for the association between PDCD6IP and TSG101. Interaction with DAPK1 can accelerate apoptotic cell death by increasing caspase-3 activity. May inhibit KDR/VEGFR2-dependent angiogenesis, the function involves inhibition of VEGF-induced phosphoprylation of the Akt signaling pathway. Seems to play a role in the regulation of the distribution and function of MCOLN1 in the endosomal pathway. Isoform 2 has a lower Ca(2+) affinity than isoform 1. Isoform 1 and, to a lesser extend, isoform 2, can stabilize SHISA5.

Molecular Weight: 21868

UniProt: O75340

Pathways: Positive Regulation of Endopeptidase Activity