EPH Receptor A2 antibody (AA 518-552)

Catalog No. ABIN6243644

This Rabbit Polyclonal antibody specifically detects EPH Receptor A2 in WB. It exhibits reactivity toward Human.

Quick Overview for EPH Receptor A2 antibody (AA 518-552) (ABIN6243644)

Target: EPH Receptor A2 (EPHA2)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EPH Receptor A2 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: RB50504

Product Details anti-EPH Receptor A2 Antibody

Binding Specificity: AA 518-552

Predicted Reactivity: Pr

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This EPHA2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 518-552 amino acids from the Central region of human EPHA2.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

Target Details for EPH Receptor A2

Target: EPH Receptor A2 (EPHA2)

Alternative Name: EPHA2

Background: Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway. May also participate in UV radiation-induced apoptosis and have a ligand- independent stimulatory effect on chemotactic cell migration. During development, may function in distinctive aspects of pattern formation and subsequently in development of several fetal tissues. Involved for instance in angiogenesis, in early hindbrain development and epithelial proliferation and branching morphogenesis during mammary gland development. Engaged by the ligand ephrin-A5/EFNA5 may regulate lens fiber cells shape and interactions and be important for lens transparency development and maintenance. With ephrin-A2/EFNA2 may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis.

Molecular Weight: 108266

UniProt: P29317

Pathways: RTK Signaling