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H2AFX antibody (Ser139)

This Rabbit Polyclonal antibody specifically detects H2AFX in WB. It exhibits reactivity toward Human.

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Catalog No. ABIN6243686

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Quick Overview for H2AFX antibody (Ser139) (ABIN6243686)

Target

See all H2AFX Antibodies

H2AFX (H2A Histone Family, Member X (H2AFX))

Reactivity

Human

Host

Rabbit

Clonality

Polyclonal

Conjugate

This H2AFX antibody is un-conjugated

Application

Western Blotting (WB)

Clone

RB43837

Discover our top product H2AFX Primary Antibody

Binding Specificity
43

21

18

10

5

5

5

4

3

3

3

3

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 134-163, Ser139

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen

This antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 134-163 amino acids from human.

Isotype

IgG
anti-H2A Histone Family, Member X (H2AFX) (AA 115-143), (C-Term) antibody
H2AFX Reactivity: Human WB, IHC (p) Host: Mouse Monoclonal 938CT5-1-1 unconjugated

anti-H2A Histone Family, Member X (H2AFX) (H2AXS139ph) antibody
H2AFX Reactivity: Human WB, ELISA, IF, ChIP Host: Rabbit Polyclonal unconjugated

anti-H2A Histone Family, Member X (H2AFX) (ubLys119) antibody
H2AFX Reactivity: Human, Mouse, Rat WB, ELISA, ICC, IHC (p), IF (p), IF (cc), IHC (fro) Host: Rabbit Polyclonal unconjugated

anti-H2A Histone Family, Member X (H2AFX) (pSer140) antibody
H2AFX Reactivity: Human WB, ELISA, ICC, IHC (p), FACS, IF (p), IF (cc), IHC (fro) Host: Rabbit Polyclonal unconjugated

anti-H2A Histone Family, Member X (H2AFX) antibody
H2AFX Reactivity: Human WB, ICC, FACS Host: Rabbit Monoclonal 23GB6040 unconjugated Recombinant Antibody

anti-H2A Histone Family, Member X (H2AFX) (H2A.XS139ph) antibody
H2AFX Reactivity: Human WB, ELISA, IF Host: Rabbit Polyclonal unconjugated

anti-H2A Histone Family, Member X (H2AFX) (AA 1-30), (N-Term) antibody
H2AFX Reactivity: Human WB, IHC (p) Host: Mouse Monoclonal 980CT1-5-5 unconjugated

anti-H2A Histone Family, Member X (H2AFX) antibody
H2AFX Reactivity: Human WB, IHC (p) Host: Mouse Monoclonal 8C5 unconjugated

anti-H2A Histone Family, Member X (H2AFX) (pSer139) antibody
H2AFX Reactivity: Human WB, IF, ICC Host: Rabbit Polyclonal unconjugated

anti-H2A Histone Family, Member X (H2AFX) (C-Term) antibody
H2AFX Reactivity: Human WB, IF, ICC, ChIP Host: Rabbit Polyclonal unconjugated

Application Notes

WB: 1:1000

Restrictions

For Research Use only
Format

Liquid

Buffer

Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative

Sodium azide

Precaution of Use

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage

4 °C,-20 °C

Expiry Date

6 months
Target

H2AFX (H2A Histone Family, Member X (H2AFX))

Alternative Name

Histone H2A.X

Background

Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C- terminal phosphorylation.

Molecular Weight

15145

UniProt

P16104

Pathways

Telomere Maintenance, DNA Damage Repair, Positive Regulation of Response to DNA Damage Stimulus