ICAM1 antibody (pTyr512)
Quick Overview for ICAM1 antibody (pTyr512) (ABIN6255938)
Target
See all ICAM1 AntibodiesReactivity
Host
Clonality
Conjugate
Application
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Binding Specificity
- pTyr512
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Specificity
- Phospho-ICAM-1 (Tyr512) Antibody detects endogenous levels of ICAM-1 only when phosphorylated at Tyrosine 512
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Cross-Reactivity
- Human, Mouse (Murine)
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Purification
- The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
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Immunogen
- A synthesized peptide derived from human ICAM-1 around the phosphorylation site of Tyrosine 512
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Isotype
- IgG
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Application Notes
- WB 1:500-1:2000 IHC 1:50-1:200, IF/ICC 1:100-1:500
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Restrictions
- For Research Use only
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Format
- Liquid
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Concentration
- 1 mg/mL
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Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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Preservative
- Sodium azide
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Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Storage
- -20 °C
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Storage Comment
- Store at -20 °C.Stable for 12 months from date of receipt
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Expiry Date
- 12 months
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- ICAM1 (Intercellular Adhesion Molecule 1 (ICAM1))
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Alternative Name
- ICAM-1
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Target Type
- Viral Protein
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Background
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Description: ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation.
Gene: ICAM1
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Molecular Weight
- 92kDa
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Gene ID
- 3383
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UniProt
- P05362
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Pathways
- Cellular Response to Molecule of Bacterial Origin, Regulation of Actin Filament Polymerization, Carbohydrate Homeostasis, Regulation of Leukocyte Mediated Immunity, Thromboxane A2 Receptor Signaling
Target
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