SAMHD1 antibody (pThr592)
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- Target See all SAMHD1 Antibodies
- SAMHD1 (SAM Domain and HD Domain 1 (SAMHD1))
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Binding Specificity
- pThr592
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This SAMHD1 antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA
- Specificity
- Phospho-SAMHD1 (Thr592) Antibody detects endogenous levels of SAMHD1 only when phosphorylated at Thr592.
- Purification
- The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
- Immunogen
- A synthesized peptide derived from human SAMHD1 around the phosphorylation site of Thr592.
- Isotype
- IgG
- Top Product
- Discover our top product SAMHD1 Primary Antibody
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- Application Notes
- WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20 °C. Stable for 12 months from date of receipt.
- Expiry Date
- 12 months
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- Target
- SAMHD1 (SAM Domain and HD Domain 1 (SAMHD1))
- Alternative Name
- SAMHD1 (SAMHD1 Products)
- Synonyms
- CHBL2 antibody, DCIP antibody, HDDC1 antibody, MOP-5 antibody, SBBI88 antibody, si:dkeyp-44b8.8 antibody, E330031J07Rik antibody, Mg11 antibody, SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 antibody, SAM domain and HD domain 1 antibody, SAM domain and HD domain, 1 antibody, SAMHD1 antibody, samhd1 antibody, Samhd1 antibody
- Background
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Description: Host restriction nuclease involved in defense response to virus. Has dNTPase activity and reduces cellular dNTP levels to levels too low for retroviral reverse transcription to occur. Blocks early-stage virus replication in dendritic and other myeloid cells. Likewise, suppresses LINE-1 retrotransposon activity. May play a role in mediating proinflammatory responses to TNF-alpha signaling (PubMed:18546154, PubMed:19525956, PubMed:22056990, PubMed:24336198, PubMed:28229507). Has ribonuclease activity, acting on single-stranded RNA. This activity is essential for H1V-1 restriction (PubMed:25038827).
Gene: SAMHD1
- Molecular Weight
- 72kDa
- Gene ID
- 25939
- UniProt
- Q9Y3Z3
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