PLCE1 antibody (C-Term)

Catalog No. ABIN6257434

The Rabbit Polyclonal anti-PLCE1 antibody (ABIN6257434) specifically detects PLCE1 in IHC, WB, ICC and IF. The antibody is reactive with Human, Mouse, Rat and Monkey samples.

Quick Overview for PLCE1 antibody (C-Term) (ABIN6257434)

Target: PLCE1 (Phospholipase C, epsilon 1 (PLCE1))

Reactivity: Human, Mouse, Rat, Monkey

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PLCE1 antibody is un-conjugated

Application: Immunohistochemistry (IHC), Western Blotting (WB), Immunocytochemistry (ICC), Immunofluorescence (IF)

Product Details anti-PLCE1 Antibody

Binding Specificity: C-Term

Purpose: PLCE1 Antibody

Specificity: PLCE1 antibody detects endogenous levels of total PLCE1

Predicted Reactivity: Bovine,Horse,Sheep

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human PLCE1, corresponding to a region within C-terminal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for PLCE1

Target: PLCE1 (Phospholipase C, epsilon 1 (PLCE1))

Alternative Name: PLCE1

Background:

Description: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. PLCE1 is a bifunctional enzyme which also regulates small GTPases of the Ras superfamily through its Ras guanine-exchange factor (RasGEF) activity. As an effector of heterotrimeric and small G-protein, it may play a role in cell survival, cell growth, actin organization and T-cell activation.

Gene: PLCE1

Gene ID: 51196

UniProt: Q9P212

Pathways: EGFR Signaling Pathway, Regulation of G-Protein Coupled Receptor Protein Signaling