SHANK2 antibody (Internal Region)

Catalog No. ABIN6275565

Product Details anti-SHANK2 Antibody

Target: SHANK2 (SH3 and Multiple Ankyrin Repeat Domains 2 (SHANK2))

Binding Specificity: Internal Region

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SHANK2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificity: SHANK2 Antibody detects endogenous levels of total SHANK2.

Predicted Reactivity: Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human SHANK2, corresponding to a region within the internal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for SHANK2

Target: SHANK2 (SH3 and Multiple Ankyrin Repeat Domains 2 (SHANK2))

Alternative Name: SHANK2 (SHANK2 Products)

Synonyms: AUTS17 antibody, CORTBP1 antibody, CTTNBP1 antibody, ProSAP1 antibody, SHANK antibody, SPANK-3 antibody, mKIAA1022 antibody, auts17 antibody, cortbp1 antibody, cttnbp1 antibody, prosap1 antibody, spank-3 antibody, shank2 antibody, MGC122482 antibody, CortBP1 antibody, Spank-3 antibody, SHANK2 antibody, SH3 and multiple ankyrin repeat domains 2 antibody, SH3 and multiple ankyrin repeat domains 2 L homeolog antibody, SH3 and multiple ankyrin repeat domains protein 2 antibody, SHANK2 antibody, Shank2 antibody, shank2.L antibody, shank2 antibody, LOC100438523 antibody

Background:

Description: Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors, and the actin-based cytoskeleton. May play a role in the structural and functional organization of the dendritic spine and synaptic junction.

Gene: SHANK2

Molecular Weight: 135 kDa

Gene ID: 22941

UniProt: Q9UPX8