TEAD3 antibody (Internal Region)

Catalog No. ABIN6257529

Product Details anti-TEAD3 Antibody

Target: TEAD3 (TEA Domain Family Member 3 (TEAD3))

Binding Specificity: Internal Region

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TEAD3 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificity: TEAD3 Antibody detects endogenous levels of total TEAD3.

Predicted Reactivity: Pig,Bovine,Horse,Sheep,Rabbit,Dog

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human TEAD3, corresponding to a region within the internal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for TEAD3

Target: TEAD3 (TEA Domain Family Member 3 (TEAD3))

Alternative Name: TEAD3 (TEAD3 Products)

Synonyms: DTEF-1 antibody, TEF-5 antibody, ETFR-1 antibody, TEAD-3 antibody, TEAD5 antibody, TEF5 antibody, Tcf13r2 antibody, cb882 antibody, tead3 antibody, TEA domain transcription factor 3 antibody, TEA domain family member 3 antibody, TEA domain family member 3 a antibody, tubby like protein 1 antibody, TEAD3 antibody, Tead3 antibody, tead3a antibody, TULP1 antibody

Background:

Description: Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to multiple functional elements of the human chorionic somatomammotropin-B gene enhancer.

Gene: TEAD3

Molecular Weight: 49 kDa

Gene ID: 7005

UniProt: Q99594

Pathways: Regulation of Lipid Metabolism by PPARalpha