LGR5 antibody (Internal Region)
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- Target See all LGR5 Antibodies
- LGR5 (Leucine-Rich Repeat Containing G Protein-Coupled Receptor 5 (LGR5))
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Binding Specificity
- Internal Region
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Reactivity
- Human, Mouse
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This LGR5 antibody is un-conjugated
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Application
- Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
- Specificity
- LGR5 Antibody detects endogenous levels of total LGR5.
- Predicted Reactivity
- Pig,Bovine,Sheep
- Purification
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogen
- A synthesized peptide derived from human LGR5, corresponding to a region within the internal amino acids.
- Isotype
- IgG
- Top Product
- Discover our top product LGR5 Primary Antibody
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- Application Notes
- WB 1:500-1:2000, IF/ICC 1:100-1:500, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Expiry Date
- 12 months
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- Target
- LGR5 (Leucine-Rich Repeat Containing G Protein-Coupled Receptor 5 (LGR5))
- Alternative Name
- LGR5 (LGR5 Products)
- Synonyms
- lgr5-a antibody, lgr5a antibody, FEX antibody, Gpr49 antibody, GPR49 antibody, GPR67 antibody, GRP49 antibody, HG38 antibody, leucine-rich repeat containing G protein-coupled receptor 5 L homeolog antibody, leucine rich repeat containing G protein coupled receptor 5 antibody, leucine rich repeat containing G protein-coupled receptor 5 antibody, lgr5.L antibody, Lgr5 antibody, LGR5 antibody
- Background
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Description: Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Involved in the development and/or maintenance of the adult intestinal stem cells during postembryonic development.
Gene: LGR5
- Molecular Weight
- 100 kDa,
- Gene ID
- 8549
- UniProt
- O75473
- Pathways
- WNT Signaling
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