H2AFZ antibody (N-Term)

Catalog No. ABIN6258940

The Rabbit Polyclonal anti-H2AFZ antibody (ABIN6258940) specifically detects H2AFZ in WB. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for H2AFZ antibody (N-Term) (ABIN6258940)

Target: H2AFZ (H2A Histone Family, Member Z (H2AFZ))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This H2AFZ antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-H2AFZ Antibody

Binding Specificity: N-Term

Purpose: Histone H2AZ Antibody

Specificity: Histone H2AZ Antibody detects endogenous levels of total Histone H2AZ.

Predicted Reactivity: Bovine,Sheep,Dog,Chicken,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human Histone H2AZ, corresponding to a region within N-terminal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:1000-3000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for H2AFZ

Target: H2AFZ (H2A Histone Family, Member Z (H2AFZ))

Alternative Name: Histone H2AZ

Background:

Description: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division.

Gene: H2AFZ

Molecular Weight: 13 kDa

Gene ID: 3015

UniProt: P0C0S5

Pathways: Telomere Maintenance