SGK3 antibody (C-Term)

Catalog No. ABIN6258948

Product Details anti-SGK3 Antibody

Target: SGK3 (serum/glucocorticoid Regulated Kinase Family, Member 3 (SGK3))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SGK3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Specificity: SGK3 Antibody detects endogenous levels of total SGK3.

Predicted Reactivity: Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human SGK3, corresponding to a region within C-terminal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Expiry Date: 12 months

Target Details for SGK3

Target: SGK3 (serum/glucocorticoid Regulated Kinase Family, Member 3 (SGK3))

Alternative Name: SGK3 (SGK3 Products)

Synonyms: CISK antibody, SGK2 antibody, SGKL antibody, 2510015P22Rik antibody, A330005P07Rik antibody, Cisk antibody, fy antibody, fz antibody, Sgkl antibody, zgc:162253 antibody, serum/glucocorticoid regulated kinase family member 3 antibody, serum/glucocorticoid regulated kinase 3 antibody, serum/glucocorticoid regulated kinase family, member 3 antibody, serine/threonine-protein kinase Sgk3 antibody, SGK3 antibody, Sgk3 antibody, LOC464217 antibody, sgk3 antibody, LOC100231693 antibody, LOC100343709 antibody, LOC100052030 antibody, LOC100521447 antibody

Background:

Description: Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, proliferation, survival and migration. Up-regulates Na+ channels: SCNN1A/ENAC and SCN5A, K+ channels: KCNA3/KV1.3, KCNE1, KCNQ1 and KCNH2/HERG, epithelial Ca2+ channels: TRPV5 and TRPV6, chloride channel: BSND, creatine transporter: SLC6A8, Na+/dicarboxylate cotransporter: SLC13A2/NADC1, Na+-dependent phosphate cotransporter: SLC34A2/NAPI-2B, amino acid transporters: SLC1A5/ASCT2 and SLC6A19, glutamate transporters: SLC1A3/EAAT1, SLC1A6/EAAT4 and SLC1A7/EAAT5, glutamate receptors: GRIA1/GLUR1 and GRIK2/GLUR6, Na+/H+ exchanger: SLC9A3/NHE3, and the Na+/K+ ATPase. Plays a role in the regulation of renal tubular phosphate transport and bone density. Phosphorylates NEDD4L and GSK3B. Positively regulates ER transcription activity through phosphorylation of FLII. Negatively regulates the function of ITCH/AIP4 via its phosphorylation and thereby prevents CXCR4 from being efficiently sorted to lysosomes.

Gene: SGK3

Molecular Weight: 57 kDa

Gene ID: 100533105, 23678

UniProt: Q96BR1