CLK4 antibody (Internal Region)

Catalog No. ABIN6260893

Product Details anti-CLK4 Antibody

Target: CLK4 (CDC-Like Kinase 4 (CLK4))

Binding Specificity: Internal Region

Reactivity: Mouse, Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CLK4 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF)

Specificity: CLK4 Antibody detects endogenous levels of total CLK4.

Predicted Reactivity: Bovine,Horse,Sheep,Dog

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human CLK4, corresponding to a region within the internal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:1000-3000, IF/ICC 1:100-1:500, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for CLK4

Target: CLK4 (CDC-Like Kinase 4 (CLK4))

Alternative Name: CLK4 (CLK4 Products)

Synonyms: AI987988 antibody, C85119 antibody, zgc:112975 antibody, CDC like kinase 4 antibody, CDC-like kinase 4 antibody, CDC-like kinase 4b antibody, CLK4 antibody, Clk4 antibody, clk4b antibody

Background:

Description: Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates SRSF1 and SRSF3. Required for the regulation of alternative splicing of MAPT/TAU. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells.

Gene: CLK4

Molecular Weight: 57 kDa

Gene ID: 57396

UniProt: Q9HAZ1