CPSF6 antibody (Internal Region)
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- Target See all CPSF6 Antibodies
- CPSF6 (Cleavage and Polyadenylation Specific Factor 6, 68kDa (CPSF6))
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Binding Specificity
- Internal Region
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Reactivity
- Human, Mouse
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This CPSF6 antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA
- Specificity
- CPSF6 Antibody detects endogenous levels of total CPSF6.
- Predicted Reactivity
- Bovine,Horse,Dog
- Purification
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogen
- A synthesized peptide derived from human CPSF6, corresponding to a region within the internal amino acids.
- Isotype
- IgG
- Top Product
- Discover our top product CPSF6 Primary Antibody
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- Application Notes
- WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20 °C. Stable for 12 months from date of receipt.
- Expiry Date
- 12 months
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- Target
- CPSF6 (Cleavage and Polyadenylation Specific Factor 6, 68kDa (CPSF6))
- Alternative Name
- CPSF6 (CPSF6 Products)
- Synonyms
- CPSF6 antibody, wu:fa22f12 antibody, zgc:85819 antibody, 4733401N12Rik antibody, AI256641 antibody, CFIM antibody, CFIM68 antibody, HPBRII-4 antibody, HPBRII-7 antibody, cleavage and polyadenylation specific factor 6 antibody, cleavage and polyadenylation specific factor 6 S homeolog antibody, CPSF6 antibody, cpsf6.S antibody, cpsf6 antibody, Cpsf6 antibody
- Background
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Description: Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs (PubMed:9659921, PubMed:8626397, PubMed:14690600, PubMed:29276085). CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals) (PubMed:9659921, PubMed:8626397, PubMed:14690600). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation (PubMed:23187700, PubMed:29276085). The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs (PubMed:20695905, PubMed:29276085). CPSF6 enhances NUDT21/CPSF5 binding to 5'-UGUA-3' elements localized upstream of pA signals and promotes RNA looping, and hence activates directly the mRNA 3'-processing machinery (PubMed:15169763, PubMed:29276085, PubMed:21295486). Plays a role in mRNA export (PubMed:19864460).
Gene: CPSF6
- Molecular Weight
- 59 kDa
- Gene ID
- 11052
- UniProt
- Q16630
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