Cyclin A antibody (C-Term)

Catalog No. ABIN6261138

There are 4+ publications for this product available. The Rabbit Polyclonal anti-Cyclin A antibody is suitable to detect Cyclin A in samples from Human, Mouse, Rat and Monkey. It has been validated for WB, IHC, IF and ICC.

Quick Overview for Cyclin A antibody (C-Term) (ABIN6261138)

Target: Cyclin A (CCNA2) (Cyclin A2 (CCNA2))

Reactivity: Human, Mouse, Rat, Monkey

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Cyclin A antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Product Details anti-Cyclin A Antibody

Binding Specificity: C-Term

Purpose: Cyclin A Antibody

Specificity: Cyclin A antibody detects endogenous levels of total Cyclin A

Predicted Reactivity: Pig,Bovine,Horse,Sheep,Rabbit,Dog

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human Cyclin A, corresponding to a region within C-terminal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:3000, IHC 1:50-1:200, IF/ICC: 1:100-1:500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

References for anti-Cyclin A antibody (ABIN6261138)

Liao, Xiao, Chen, Zhang, Chen, Long, Gao, He, Ge, Yi, Wu, Li, Zhou: "The receptor for activated protein kinase C promotes cell growth, invasion and migration in cervical cancer." in: International journal of oncology, Vol. 51, Issue 5, pp. 1497-1507, (2018) (PubMed).

Huang, Song, Tao, Shao, Zeng, Xu, Qi, Sun: "Ovostatin 2 knockdown significantly inhibits the growth, migration, and tumorigenicity of cutaneous malignant melanoma cells." in: PLoS ONE, Vol. 13, Issue 4, pp. e0195610, (2018) (PubMed).

Liao, Xiao, Chen, Zhang, Chen, Long, Gao, Zhu, He, Peng, Xiong, Zeng, Li, Zhou, Li, Ma, Wu, Xiang, Li, Zhou: "CD38 enhances the proliferation and inhibits the apoptosis of cervical cancer cells by affecting the mitochondria functions." in: Molecular carcinogenesis, Vol. 56, Issue 10, pp. 2245-2257, (2017) (PubMed).

Chen, Suo, Cheng, Zheng, Xu: "Vascular endothelial growth factor C enhances cervical cancer migration and invasion via activation of focal adhesion kinase." in: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, Vol. 29, Issue 1, pp. 20-4, (2013) (PubMed).

Target Details for Cyclin A

Target: Cyclin A (CCNA2) (Cyclin A2 (CCNA2))

Alternative Name: Cyclin A

Background:

Description: May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells.

Gene: CCNA1

Molecular Weight: 53kDa

Gene ID: 8900

UniProt: P78396

Pathways: PI3K-Akt Signaling, Cell Division Cycle, AMPK Signaling, Mitotic G1-G1/S Phases, DNA Replication, M Phase, Synthesis of DNA