ICOS antibody (Internal Region)

Catalog No. ABIN6262438

Product Details anti-ICOS Antibody

Target: ICOS (Inducible T-Cell Co-Stimulator (ICOS))

Binding Specificity: Internal Region

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ICOS antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Specificity: ICOS Antibody detects endogenous levels of total ICOS.

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human ICOS, corresponding to a region within the internal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for ICOS

Target: ICOS (Inducible T-Cell Co-Stimulator (ICOS))

Alternative Name: ICOS (ICOS Products)

Synonyms: ICOS antibody, AILIM antibody, CCLP antibody, CRP-1 antibody, H4 antibody, Ly115 antibody, CD278 antibody, CVID1 antibody, Ailim antibody, inducible T-cell costimulator antibody, inducible T cell co-stimulator antibody, inducible T-cell co-stimulator antibody, ICOS antibody, LOC100232284 antibody, Icos antibody

Background:

Description: Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes (By similarity).

Gene: ICOS

Molecular Weight: 23kDa

Gene ID: 29851

UniProt: Q9Y6W8

Pathways: Cancer Immune Checkpoints