KPNA4 antibody (C-Term)

Catalog No. ABIN6262864

Product Details anti-KPNA4 Antibody

Target: KPNA4 (Karyopherin (Importin) alpha 4 (KPNA4))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KPNA4 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificity: KPNA4 Antibody detects endogenous levels of total KPNA4.

Predicted Reactivity: Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human KPNA4, corresponding to a region within C-terminal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for KPNA4

Target: KPNA4 (Karyopherin (Importin) alpha 4 (KPNA4))

Alternative Name: KPNA4 (KPNA4 Products)

Synonyms: IPOA3 antibody, QIP1 antibody, SRP3 antibody, 6 antibody, ATIMPALPHA3 antibody, IMPA-3 antibody, IMPORTIN ALPHA 3 antibody, IMPORTIN ALPHA ISOFORM 3 antibody, MODIFIER OF SNC1 antibody, T10M13.16 antibody, T10M13_16 antibody, LOC100224013 antibody, 1110058D08Rik antibody, importin antibody, ipoa3 antibody, qip1 antibody, srp3 antibody, impa3 antibody, wu:fa56d07 antibody, wu:fa66g10 antibody, wu:fe14c04 antibody, wu:fi04h11 antibody, wu:fi19b05 antibody, karyopherin subunit alpha 4 antibody, ARM repeat superfamily protein antibody, importin alpha 3 antibody, karyopherin (importin) alpha 4 antibody, karyopherin alpha 4 (importin alpha 3) S homeolog antibody, karyopherin alpha 4 (importin alpha 3) antibody, KPNA4 antibody, MOS6 antibody, LOC100533341 antibody, Kpna4 antibody, kpna4.S antibody, kpna4 antibody

Background:

Description: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS.

Gene: KPNA4

Molecular Weight: 57kDa

Gene ID: 3840

UniProt: O00629

Pathways: Protein targeting to Nucleus