Mahogunin RING Finger Protein 1 antibody (Internal Region)

Catalog No. ABIN6264784

Product Details anti-Mahogunin RING Finger Protein 1 Antibody

Target: Mahogunin RING Finger Protein 1 (MGRN1) (Mahogunin, Ring Finger 1 (MGRN1))

Binding Specificity: Internal Region

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Mahogunin RING Finger Protein 1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Specificity: RNF156 Antibody detects endogenous levels of total RNF156.

Predicted Reactivity: Pig,Bovine,Horse,Rabbit,Dog,Chicken,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human RNF156, corresponding to a region within the internal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000, IHC 1:50-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for Mahogunin RING Finger Protein 1

Target: Mahogunin RING Finger Protein 1 (MGRN1) (Mahogunin, Ring Finger 1 (MGRN1))

Alternative Name: MGRN1 (MGRN1 Products)

Synonyms: RNF156 antibody, 2610042J20Rik antibody, mKIAA0544 antibody, md antibody, nc antibody, RGD1311862 antibody, mgrn1 antibody, wu:fi38c03 antibody, zgc:55978 antibody, mahogunin ring finger 1 antibody, mahogunin, ring finger 1 antibody, mahogunin ring finger 1, E3 ubiquitin protein ligase S homeolog antibody, mahogunin ring finger 1, E3 ubiquitin protein ligase antibody, mahogunin, ring finger 1a antibody, MGRN1 antibody, Mgrn1 antibody, mgrn1.S antibody, mgrn1 antibody, mgrn1a antibody

Background:

Description: E3 ubiquitin-protein ligase. Mediates monoubiquitination at multiple sites of TSG101 in the presence of UBE2D1, but not of UBE2G1, nor UBE2H. Plays a role in the regulation of endosome-to-lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production. Does not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination. Acts also as a negative regulator of hedgehog signaling (By similarity).

Gene: MGRN1

Molecular Weight: 66-72 kDa,55 kDa

Gene ID: 23295

UniProt: O60291

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling